In the dog, neoplasms of the lacrimal gland are rare. Pleomorphic adenoma with sarcomatous change in a lacrimal gland. Clinical sciences malignant epithelial tumors of the. The primary epithelial tumors of the lacrimal gland can be generally classified into two groups, benign and malignant lesions. In his study, wright reported that 39 of 40 cases diagnosed with primary malignant lacrimal gland tumors had a painful mass. By histopathology and clinical evaluation, 79% of lacrimal gland tumors were benign. Jun 22, 2020 lacrimal gland tumors are among the rarest types of head and neck cancers, accounting for approximately 10% of all orbital tumors. Original article outcomes of malignant tumors of the. On ct, adenoid cystic carcinoma appears as a welldefined, homogeneous, and unilat eral solid mass involving the orbital lobe of the lacrimal. Epithelial tumors of the lacrimal gland in the chinese. Erosion of the orbital plate frontal bone by a benign tumor.
Previous studies have estimated annual incidence for these tumors at 0. Malignant mixed tumour arising in lacrimal gland is rarely described. The lacrimal gland is considered to be a minor salivary gland that shares histologic features with the major salivary glands. A pleomorphic adenoma of the lacrimal gland in a dog. Adenoid cystic carcinoma of the lacrimal gland simulating. The most common lacrimal gland tumors include idiopathic orbital inflammation 46. Tumors and lesions involving the lacrimal gland and its fossa are important in the differential diagnosis of orbital lesions and present special problems in.
Having no signs of a tumor after finishing treatment. Primary lacrimal gland tumors arising from epithelial cells are relatively common, accounting for 20% of all solid lacrimal gland masses. Residual glands were serous, and the majority of tumor cells were negative for mucin. Debulking of the orbital lobe of the lacrimal gland may offer improved control rates in dacryoadenitis without compromise of tear film function. Lacrimal gland lesions generally present as palpable masses in the superolateral aspects of the orbits. Improvements have been made in the understanding of lacrimal gland lesions with the knowledge that lacrimal gland. Anterior and posterior lacrimal crests form the lacrimal sac fossa anterior medial. Abstract tumours of the lacrimal gland are rare, but the prognosis may be grave. Lacrimal gland tumors uscap meeting evaluations and cmesam. In one study by lloyd,1 only 8 out of 212 cases of proptosis were caused by lacrimal tumors. Most patients with malignant epithelial tumors present with painful swelling in the upper eyelid that developed within one year. The symptoms and findings of a lacrimal gland lesion are a growing mass at the site of the lacrimal.
This subtype of lacrimal gland, adenocarcinoma, was described for the first time in 1996 by katz et al. Histologically these neoplasms revealed a similarity in structure to mixed pleomorphic adenomas of the salivary glands,14 with some showing. This paper presents the clinical and pathological findings in 40 consecutive patients seen with primary tumours arising from the lacrimal gland. There are different types of lacrimal gland cancer. Lacrimal gland tumors are considered one of the challenging types of tumor which are difficult to study because of their rare incidence as they represent almost only 10% of the space occupying orbital lesions.
Orbital nerve sheath tumors presenting in the lacrimal fossa region are. Rarely, vascular tumors, such as cavernous or epithelioid hemangioma, hemangioendothelioma, or hemangiopericytoma arise in the lacrimal fossa. It has been described that about 50% of lacrimal masses are epithelial and 50%. You will read about how to cope with challenges in everyday life after a diagnosis of a lacrimal gland tumor. Clinical presentation and management of lacrimal gland tumours. Adenocarcinoma background malignant epithelial tumors of the lacrimal gland are rare and constitute less than 5% of all biopsied orbital lesions 1. In patients with recurrent or metastatic disease, a search for actionable cancer associated mutations may be prudent. In 1518 patients, tumor involved both the lacrimal sac and duct at the time of diagnosis. Pdf on jun 29, 2018, maya hada and others published lacrimal gland tumors. Until recently, primary adenocarcinomas of the lacrimal gland were notfurther subclassi. Pdf an update on tumors of the lacrimal gland researchgate.
Expression profile of tumor suppressor gene rassf1 in lacrimal gland carcinoma. Adenoid cystic carcinoma is the most common primary malignant epithelial tumor of the lacrimal gland. Primary malignant neoplasms of the lacrimal gland british journal. Lacrimal gland tumors account for about 915% of all orbital tumors and represent a particularly difficult group with respect to diagnosis and management. Lacrimal gland adenocarcinoma is extremely rare, comprising 2. Review introduction primary ductal adenocarcinoma of lacrimal gland pdalg has emerged as a distinct subtype of lacrimal gland adenocarcinoma 1 that accounts for 2% of all epithelial lacrimal gland tumors 2. The symptoms and findings of a lacrimal gland lesion are a growing mass at the site of the lacrimal gland, including displacement of the eyeball. The supraorbital location, encapsulation, and residual serous glands suggest that this mass was a lowgrade adenocarcinoma of the lacrimal gland. They presented in a recognisable clinical manner with a painless mass in the region of the lacrimal gland which slowly enlarged over a period of at least. This causes proptosis and, if enlargement of the gland is rapid, may even produce diplopia. Pdf intracranial metastatic lacrimal gland tumour jafri.
Objectiveto apply the updated epithelial salivary gland classification scheme to a large cohort of lacrimal gland tumors so as to provide an updated lacrimal gl. This is more likely to be diagnosed in people around the age of 70 years. Pathology inflammatory sarcoidosis affects 25% of patients with systemic diseas. Lacrimal gland masses can be classified into two broad groups inflammatory 50% and neoplastic, either lymphoma 25% or salivary gland type tumors 25%. Benign mixed tumor pleomorphic adenoma of the lacrimal gland in a 6yearold boy. Feb 03, 2020 malignant tumors of the lacrimal gland include adenoid cystic carcinoma, adenocarcinoma, squamous cell carcinoma, mucoepidermoid carcinoma, and malignant lymphomas. Oct 12, 1981 lacrimal gland tumors as a whole account for only a small percentage of patients presenting with proptosis.
Pleomorphic adenoma of lacrimal gland journal of surgical. Among the epithelial lesions, 55% are benign and 45% are malignant 1. Lacrimal gland tumor capt ayinun nahar trainee in ophthalmology cmh,dhaka 2. Overview of benign and malignant lacrimal gland tumors. Androgen receptor ar expression and deprivation combined with checkpoint inhibition cpi have not been described before in lacrimal gland adenocarcinoma.
However, when malignant transformation of lgpa has occurred, most of the reports were. Complete excision with adjuvant radiotherapy is recommended. Outcomes in patients with lacrimal gland carcinoma treated with. Lacrimal gland adenocarcinoma with apocrine metaplasia. Clinical presentation and management of lacrimal gland. Among malignant tumours originating in salivary glands and lacrimal glands, adenoid cystic carcinoma is seen most. The word survivorship means different things to different people. Sep 11, 2017 because there is no specific histopathologic classification for lacrimal gland tumors, they are often classified according to the histological classification of salivary gland tumors with which they share many similarities 1, 3, 7. According to a clinical series from the wills eye hospital, lacrimal gland tumors represent almost 10% of the space occupying orbital lesions, with epithelial.
In selected patients with lacrimal gland carcinoma, eyesparing surgery with eyesparing radiation therapy offers preservation of visual function with good local control and minimal radiationinduced ocular toxic effects. Tumors of the lacrimal gland have an incidence of 1 case per 1,000,000 persons per year and constitute approximately one quarter of orbital spaceoccupying lesions with the majority being benign. Request pdf on jan 31, 2010, petros aristodemou published lacrimal gland tumor outcomes find, read and cite all the research you need on researchgate. Imaging features of malignant lacrimal sac and nasolacrimal. Incidence of orbital, conjunctival and lacrimal gland. Request pdf on jan 1, 2005, yoonduck kim and others published lacrimal gland tumors find, read and cite all the research you need on researchgate. Although adenocystic carcinoma is the most frequent orbital epithelial malignancy, lacrimal gland adenocarcinoma has a. Lacrimal gland tumors are considered one of the challenging types of tumor which are difficult to study because of their rare incidence as they represent almost. Malignant mixed tumor carcinoma ex pleomorphic adenoma. The most common tumor histology in our series was squamous cell carcinoma.
Lacrimal gland adenocarcinoma responding to checkpoint. Ductal carcinoma, defined by its resemblance to mammary ductal carcinoma, has only recently been reported in the lacrimal gland, and to our knowledge 1 of our 2 cases was the first reported in the lacrimal gland. Erosion of the orbital plate frontal bone by a benign. To report a case of acinic cell carcinoma occurred in the lacrimal gland. Among malignant tumours originating in salivary glands and lacrimal glands, adenoid cystic carcinoma is seen most frequently. Results incidence we have collected 120 cases of lacrimal gland masses during a 23year period table1. Eyepreserving surgery, as opposed to exenteration, followed by adjuvant. Malignancy must be considered for cases with pain and progredien symptoms. Lacrimal gland tumors are rare but highly aggressive salivary gland tumors. Lacrimal gland tumors are rare and constitute a wide spectrum of different entities ranging from benign epithelial and lymphoid lesions to highgrade carcinomas, lymphomas, and sarcomas with large.
Orbital tumors showed a higher incidence rate followed by conjunctival and lacrimal gland tumors with incidence rates of 1. Intoduction lacrimal gland tumors are rare, representing only 518% of orbital spaceoccupying lesions they have an estimated incidence of 1 per 1 million people per year they are more prevalent in elderly. Pediatric orbital tumors and lacrimal drainage system. The optimal treatment for lacrimal gland cancer remains unclear.
Mostofthe inflammatory masses were chronic dacryoadenitis, either of. Lacrimal gland tumors are rare and constitute a wide spectrum of different entities ranging from benign epithelial and lymphoid lesions to highgrade carcinomas, lymphomas, and sarcomas with large differences in prognosis and clinical management. Pdf lacrimal gland tumors are rare and constitute a wide spectrum of different entities ranging from benign epithelial and lymphoid lesions to. To see other pages, use the menu on the side of your screen. Among the epithelial tumors of the lacrimal gland, approximately 50% are pleomorphic adenomas benign mixed tumors, 25% adenoid cystic carcinoma, and the remainders are other types of carcinoma. Lacrimal gland tumors using proposed salivary gland classification scheme diagnosis cases, no. Lacrimal gland tumors tumors of the lacrimal gland. There were 40 cases of benign or malignant epithelial lacrimal gland tumours. Mitotic figures were common, with a rate of 9 mitotic figures per 10 highpower fields. Pleomorphic adenoma with sarcomatous change in a lacrimal. Hence, in many respects, lacrimal gland tumors resemble those that arise in the major salivary glands.
Original article outcomes of malignant tumors of the lacrimal. Few lacrimal gland tumors have been reported in humans and animals. Pdf epidemiological trends in malignant lacrimal gland. Approximately 50% of lacrimal gland masses are inflammatory lesions, 25% are lymphoid lesions or lymphoma, and the other 25% are salivary gland type tumors. They typically present as unilateral lacrimal gland enlargement with inferomedial displacement of the eye.
Outcomes in patients with lacrimal gland carcinoma treated. Tumors arising from lacrimal glands, which are rare and account for 9% of all orbital tumors, can be classified into epithelial 40% and lymphoid 60% tumors. An overview find, read and cite all the research you need. Lacrimal gland tumor an overview sciencedirect topics. These neoplasms are locally invasive, recur after attempted resection, but are not known to metastasize following what is usually a brief postoperative followup period. Inflammation and infiltration are much more common causes of bilateral lacrimal gland swelling with sarcoidosis, lymphoma and leukemia. Although tumors and infection can cause lacrimal gland swelling they rarely do so bilaterally. Adenocarcinomas have known to have driver mutations in nonsmall cell lung cancer, however, besides her2 expression not much is known regarding molecular drivers in lacrimal tumors. The tumor should be removed en bloque, without violating its pseudocapsule why must a pleomorphic adenoma be managed in this way. The trend line of overall incidence of tumors showed a significant increase apc3. The purpose of this study was to present the imaging features of primary and secondary malignant lacrimal sac and nasolacrimal duct tumors and their pattern of tumor spread in 18 patients. Lacrimal gland tumours are rare, but the patients are relatively young and. Most of the benign lesions are the pleomorphic adenoma of the lacrimal gland lgpa 3,5,7,8,19, which is composed of both epithelial and stromal components 14,19. A person who has lymphoma can slightly increase the risk of developing lymphoma of the lacrimal gland.
Lacrimal gland tumors represent 5% to 25% of orbital tumors1. The symptoms and findings of a lacrimal gland lesion. The use of the more histologically diverse classification of salivary gland tumors can be successfully applied to the epithelial lacrimal gland neoplasms. Orbital adenocarcinoma of lacrimal gland origin in a dog. Clinical management of acinic cell carcinoma of the lacrimal.
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